Muscle Relaxers: Methocarbamol vs Cyclobenzaprine

Muscle Relaxers: Methocarbamol vs Cyclobenzaprine

Call 911 or go to the nearest emergency room if your symptoms are severe. Do not take this drug again if you’ve ever had an allergic reaction to it. When certain drugs are used with cyclobenzaprine, they may cause more severe side effects such as increased drowsiness or sedation.

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At oral doses of up to 10 times the human dose, cyclobenzaprine did not adversely affect the reproductive performance or fertility of male or female rats. Cyclobenzaprine did not demonstrate mutagenic activity in the male mouse at dose levels of up to 20 times the human dose. Acute recovery phase of myocardial infarction, and patients with arrhythmias, heart block or conduction disturbances, or congestive heart failure.


Neither Chlorzoxazone or Flexeril should be taken if you are consuming alcohol or drugs that depress the central nervous system (CNS), like sleep aids and sedatives. Always inform your doctor about any medication you are currently on; CNS depressants will need to be reduced slowly from your regimen due to potential dangerous interactions with chlorzoxazone and flexeril. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes, thus relaxing muscles.

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Cyclobenzaprine may also be used for purposes not listed in this medication guide. If you are not able to swallow the extended-release capsule whole, mix the contents of the capsule with applesauce. After you eat the mixture, take a drink, and swish and swallow to make sure that you have received all the medication.

Centrally Acting Skeletal Muscle Relaxants and Associated Drugs

Drug interactions and side effects are always possible when taking a muscle relaxer or any other prescription drug. For that reason, you should consider a few risk factors before taking cyclobenzaprine, whether it’s for muscle pain and discomfort or to facilitate better sleep habits in the short term. Cyclobenzaprine is a centrally acting skeletal-muscle relaxant, claimed to be effective in providing relief of muscle spasm, pain and tenderness, and in reducing the limitations imposed thereby on normal daily activities. It is structurally similar to the tricyclic antidepressants and adverse effects similar to those seen with the tricyclic antidepressants are therefore to be expected. Robaxin is the brand name of the generic medication called methocarbamol. It was developed in the 1960s to treat pain and provide relief from muscle spasms.

Rinse the mouth to make sure all of the medicine have been swallowed. Do not take more of it and do not take it more often than your doctor ordered. Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Do not flush medications down the toilet or pour them into a drain unless instructed to do so.

  • Unlike Chlorzoxazone, Flexeril does not directly act on the muscles; instead it primarily acts within the central nervous system at brain stem level.
  • This product may contain inactive ingredients, which can cause allergic reactions or other problems.
  • Admitting your substance use has gotten out of control can save your life.
  • The use of significant lower dosing schedules in elderly patients may be prudent.
  • People with glaucoma, increased eye pressure, liver disease, and difficulty urinating may not react well to this particular muscle relaxer.
  • Safety and effectiveness of FLEXERIL in pediatric patients below 15 years of age have not been established.

Cyclobenzaprine’s plasma concentrations average 40% higher in the elderly, making these patients more at risk of the drug’s harmful effects. If you’re taking Flexeril non-medically for a high—with or without other drugs—treatment for substance abuse can prevent you from suffering a dangerous overdose. Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation, or trouble urinating.

Hyperpyretic crisis seizures, and deaths have occurred in patients receiving cyclobenzaprine (or structurally similar tricyclic antidepressants) concomitantly with MAO inhibitor drugs. Some medicines can interact with cyclobenzaprine and cause a serious condition called serotonin syndrome. Ask your doctor before making any changes in how or when you take your medications.

Cyclobenzaprine also lasts longer in your system than tizanidine, with half-lives of 18 and 2.5 hours, respectively. The side-effect profile is similar between both drugs as they are generally well-tolerated. However, drowsiness or lightheadedness may occur more frequently with flexeril compared to chlorzoxazone. Patients must closely monitor their condition when starting treatment on either drug and should seek medical help immediately if there are any signs of allergic reactions or worsening symptoms. With both Chlorzoxazone and Flexeril, as with most other muscle relaxant medications, there can be certain adverse effects. If you notice symptoms such as extreme drowsiness, confusion or weakness become more severe after starting these medications, please seek immediate medical attention.

Tizanidine is a prescription muscle relaxant that’s used to alleviate pain and muscle spasms that are caused by spinal injuries. The drug can also be used to treat spasticity that’s caused by neurological disorders that damage the nerves like multiple sclerosis. Tizanidine is helpful when it’s used in conjunction with physical therapy.

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